Design and synthesis of a Multi Domain Peptide to inhibit the aggregation of Amyloid-Beta involved in the Alzheimer’s disease


Alzheimer is the third cause of death in individuals aging above 60, after heart disease and cancer. The disease is diagnosed by the loss of thinking, remembering, reasoning and cognition function and effects person's daily life. It has been discovered that the main cause of Alzheimer is the aggregation of Amyloid Beta peptides in brain, which interrupt the neurons connection and destroy brain cells. It may be hypothesized that a cure could be developed by preventing the aggregation process. In this research, a series of multi-domain peptides with different sequences are to be synthesized and checked for their effect on the aggregation of Amyloid Beta. Due to the presence of both hydrophobic and hydrophilic domains in such peptides, it is hypothesized that they can interact with Amyloid Beta peptide, and interfere with its aggregatio

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